Which dosage form is a semisolid in a non-fatty base used for topical application and contains fine particles?

Which dosage form is a semisolid in a non-fatty base used for topical application and contains fine particles?

• A. Gels
• B. Emulsions
• C. Creams
• D. Ointments

Answer: (A)

Topical semisolids differ by their base. A non-fatty, water-based vehicle forms a gel when a gelling agent thickens the liquid, creating a jelly-like structure. This type of matrix is able to suspend or disperse fine drug particles, giving a semisolid texture without greasiness. That combination—semisolid, non-fatty, and capable of holding fine particles—fits gels best. In contrast, ointments are greasy oil-based preparations, and creams are emulsions that typically incorporate a fat phase, making them less distinctly non-fatty. So, the description points to a gel.

Topical semisolids differ by their base. A non-fatty, water-based vehicle forms a gel when a gelling agent thickens the liquid, creating a jelly-like structure. This type of matrix is able to suspend or disperse fine drug particles, giving a semisolid texture without greasiness. That combination—semisolid, non-fatty, and capable of holding fine particles—fits gels best. In contrast, ointments are greasy oil-based preparations, and creams are emulsions that typically incorporate a fat phase, making them less distinctly non-fatty. So, the description points to a gel.